Genome-wide linkage analysis of bronchodilator responsiveness and post-bronchodilator spirometric phenotypes in chronic obstructive pulmonary disease
نویسندگان
چکیده
منابع مشابه
Correlation between bronchodilator responsiveness and quality of life in chronic obstructive pulmonary disease.
BACKGROUND Guidelines and literature debate the importance of testing for bronchial reversibility and its total significance is unclear. Clinically, patients with greater reversibility have higher fluctuations in respiratory symptoms, and hence may have a reduced health-related quality of life (HRQoL). On the other hand, they may have a better HRQoL as medications may be more effective in this ...
متن کاملspirometric indices after bronchodilator test in obstructive lung disease
bronchial responsiveness to bronchodilator medications is usually tested to establish reversibility of airflow obstruction. among the various tests to establish bronchodilator response, fev1, fef25-75% or fef50%, and fvc are the most widely used. in a cross-sectional study, we assessed spirometric responses after administration of bronchodilator in 187 workers with obstructive pattern in spirom...
متن کاملCHRONIC OBSTRUCTIVE PULMONARY DISEASE Bronchodilator reversibility testing in chronic obstructive pulmonary disease
Background: A limited or absent bronchodilator response is used to classify chronic obstructive pulmonary disease (COPD) and can determine the treatment offered. The reliability of the recommended response criteria and their relationship to disease progression has not been established. Methods: 660 patients meeting European Respiratory Society (ERS) diagnostic criteria for irreversible COPD wer...
متن کاملSmall airway dysfunction and flow and volume bronchodilator responsiveness in patients with chronic obstructive pulmonary disease
BACKGROUND We investigated whether a relationship between small airways dysfunction and bronchodilator responsiveness exists in patients with chronic obstructive pulmonary disease (COPD). METHODS We studied 100 (20 female; mean age: 68±10 years) patients with COPD (forced expiratory volume in 1 second [FEV1]: 55% pred ±21%; FEV1/forced vital capacity [FVC]: 53%±10%) by impulse oscillometry sy...
متن کاملThe bronchodilator test in chronic obstructive pulmonary disease: interpretation methods.
The objective of the study was to evaluate the best method for interpreting the bronchodilator test (BDT). Five formulas for expressing the BDT results were analyzed and compared: changes experienced by maximum expiratory volume in 1s (FEV(1)) and forced vital capacity (FVC) measured in milliliters, in percentage with respect to the baseline, in percentage with respect to the predicted, in perc...
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ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 2003
ISSN: 1460-2083
DOI: 10.1093/hmg/ddg207